Evaluation of the Resistance Pattern of Escherichia Coli and Klebsiella Pneumoniae Against Beta Lactam and Non Beta Lactam Antibiotics

This study was designed to determine Escherichia coli and Klebsiella pneumoniae resistance pattern to some beta and non-beta lactam antibiotics currently in use. Fifty (50) samples (25 stool sample and 25 sputum sample) were collected and cultured using streak method of inoculation. Fifteen (15) isolates of Klebsiella pneumoniae was gotten from sputum samples and 15 isolates of E.coli gotten from stool samples. Disc diffusion method was adopted for the antimicrobial assay. Out of the 15 isolates of E.coli tested, 93.3% were susceptible to ciprofloxacin, 80.0% to Gentamicin, 86.7% to Oflaxacin,73.3% to sulfamethoxazole and 80.0% to Nitrofurantoin, while all were resistant to amoxicillin. Klebsiella pneumoniae showed 80.0% susceptibility to ciprofloxacin, 73.3% to Gentamicin, 80.0% to Oflaxacin and 100.0% and 93.3% resistance to sulfamethoxazole and Nitrofurantoin respectively. For the beta-lactam antibiotics, 80.0% susceptibility to ceftazidime was recorded against Klebsiella pneumoniae. There was no significant difference (p=0.05) in activity between the beta-lactam drugs and the non-beta-lactam drugs against the isolates. Therefore, any of the drugs from these groups could be used in the treatment of infections caused by these test isolates.